Xuanmao Jiao, Ph.D

Status

Dr. Xuanmao Jiao is currently the an Associate Professor in the Pennsylvania Cancer and Regenerative Medicine Research Center, a part of the Baruch S. Blumberg Institute in Doylestown, Pennsylvania.  He previously held the position of Instructor, Department of Cancer Biology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA

 

background

Jiao has been focusing on the research using CCR5 antagonists to block breast and prostate cancer tumor metastasis and tumorigenesis. An clinical trial based on these research is ongoing and preliminary results are encouraging. His other researches is trying to elucidate the molecular mechanisms of the effects of oncogenes and tumor suppressors on tumor metastasis, tumorigenesis and cancer stem cell self-renewal/expansion. The oncogenes and tumor suppressors he studied include cyclin D1, Dach1, c-Jun, Akt, Notch1 and NFkB. He also has extensive experience and expertise on chemotaxis, vaccine development, liposome technology, membrane fusion and mitochondria functions. As the first, equal first, corresponding or co-corresponding author on 31 original research papers and 8 reviews, Jiao totally published 81 original research papers and 15 reviews in peer-reviewed journals with H-index 39 and 5258 citations. He was invited to serve as Associate Editor in both “Molecular and Cellular Oncology” and  “Cancer cell signaling” sections of the journal “Frontiers in Oncology” and Review Editor in “Molecular and Cellular Pathology” section of the journal “Frontiers in  Cell and Developmental Biology”. He was also invited to be the Guest Editor for a special issue “The Role of G Protein-Coupled Receptor in Human Disease” in the journal “International Journal of Molecular Sciences”. As mentors, 14 postdocs and PhD students were benefited from his instruction. He is the director of the joint program “Introduction to Clinical Research” between his institute and Xavier University School of Medicine at Aruba. So far, 129 MD students have been trained in this program.

 

Contributions to Science

The Role of chemokine and chemokine receptor in cell migration and tumor metastasis. Jiao and his collaborators found that CCR5 antagonists, originally developed as HIV entry inhibitors, reduces invasiveness and metastatic capability of breast and prostate cancer cells both in vitro and in vivo, with immediate clinical implications for evaluation as anti-metastatic drugs. They found that CCR5 play the role in breast cancer stem cell expansion and DNA damage repair. CCR5 antagonists can lower the doxorubicin dosage for chemotherapy, thus may reduce side effects of doxorubicin. They showed that IL-8 can induce partitioning of human CXCR1 chemokine receptors to lipid raft thus facilitate G-protein-dependent signaling. They elucidated that the tumor suppressor Dach1 reduces breast and prostate cancer metastasis through inhibiting IL8/CXCR1/2 axis. They showed that the PI3 kinase is the compass to sense chemoattractant gradient in chemotaxis.

The Role of c-Jun, a proto-oncogene, in breast cancer metastasis and tumorigenesis. Jiao and his collaborators found that c-Jun induces mammary tumor cellular invasion and breast cancer stem cell expansion. They showed that disruption of c-Jun reduces cellular migration and invasion through inhibition of CCL5, c-Src, SCF and hyperactivation of ROCK II Kinase. They also found that c-Jun is required for TGF-β-mediated cellular migration via nuclear Ca2+ signaling and play the role in alternative splicing.

The role of cyclin D1 in DNA damage/repair, cell migration, EMT and stem cell expansion. Jiao and his collaborators showed that cyclin D1 can promote cell migration. The role of cyclin D1 in cell migration is through the inhibition of thrombospondin-1 and ROCK signaling and requiring p27kip1. The different cyclin D1 alternative splicing forms have different function in cell migration, p27kip1 binding and DNA damage/repair responses. They showed that cyclin D1 play the role in G9a mediated DNA methylation and P300 mediated DNA acetylation. They found that cyclin D1 promotes the rate of onset and magnitude of mitogenic signaling via Akt1 Ser473 phosphorylation. They found the role of cyclin D1 in prostate cancer and promotes v-Src induced Trop2 proteolytic activation and thus influence prostate cancer stem cells expansion and differentiation. They showed that elevation of cyclin D1 in cancer stromal cells promotes heterotypic immune signaling and thus promotes cancer growth. They found that cyclin D1 can localized in cellular membrane region and membrane associated cyclin D1 enhance cell migration. They also found the role of cyclin D1 in autophagy, mitochondria function and Notch signaling.

The role of Dach1 in breast and prostate cancer tumorigenesis and metastasis. Dach1 was initially cloned as a gene governing eye development. Jiao and his collaborators found the role of Dach1 in tumorigenesis. They elucidated that Dach1 restrains tumor growth through block c-Jun/YB-1 binding to transcription factor binding site. They found that the abundance of Dach1 is reduced in human cancers and Dach1 restrains stem cell expansion through reprogramming an Oct/Nanog/EKLF pathways. They found that Dach1 restrained both breast and prostate cancer cell migration and tumor metastasis and elucidated that the Dach1 reduces breast and prostate cancer metastasis through inhibiting IL8/CXCR1/2 axis.

Development of HCV vaccines. Jiao and his collaborators developed vaccines targeted Hepatitis C Virus nonstructural protein 3 with DNA-encoded secreted protein, cationic liposome encapsulated DNA or co-delivery of CpG and protein to Enhance and modulation of Th1 cellular immune response against HCV.

 

Publications

  1. Hu J, Wang SG, Hou Y, Chen Z, Liu L, Li R, Li N, Zhou L, Yang Y, Wang L, Wang L, Yang X, Lei Y, Deng C, Li Y, Deng Z, Ding Y, Kuang Y, Yao Z, Xun Y, Li F, Li H, Hu J, Liu Z, Wang T, Hao Y, Jiao X, Guan W, Tao Z, Ren S, Chen K. Multi-omic profiling of clear cell renal cell carcinoma identifies metabolic reprogramming associated with disease progression. Nat Genet. 2024 Feb 15. doi: 10.1038/s41588-024-01662-5. Epub ahead of print. PMID: 38361033

  2. Jiao X, Di Sante G, Casimiro MC, Tantos A, Ashton AW, Li Z, Quach Y, Bhargava D, Di Rocco A, Pupo C, Crosariol M, Lazar T, Tompa P, Wang C, Yu Z, Zhang Z, Aldaaysi K, Vadlamudi R, Mann M, Skordalakes E, Kossenkov A, Du Y, Pestell RG. A cyclin D1 intrinsically disordered domain accesses modified histone motifs to govern gene transcription. Oncogenesis. 2024 Jan 8;13(1):4. doi: 10.1038/s41389-023-00502-1. PMID: 38191593; PMCID: PMC10774418

  3. (Equal first author) Li Z, Jiao X, Robertson AG, Di Sante G, Ashton AW, DiRocco A, Wang M, Zhao J, Addya S, Wang C, McCue PA, South AP, Cordon-Cardo C, Liu R, Patel K, Hamid R, Parmar J, DuHadaway JB, Jones SJM, Casimiro MC, Schultz N, Kossenkov A, Phoon LY, Chen H, Lan L, Sun Y, Iczkowski KA, Rui H, Pestell RG. The DACH1 gene is frequently deleted in prostate cancer, restrains prostatic intraepithelial neoplasia, decreases DNA damage repair, and predicts therapy responses. Oncogene. 2023 Apr 24. doi: 10.1038/s41388-023-02668-9. Epub ahead of print. PMID: 37095257

  4. (Corresponding author) Jiao X, Wang M, Zhang Z, Li Z, Ni D, Ashton AW, Tang HY, Speicher DW, Pestell RG. Leronlimab, a humanized monoclonal antibody to CCR5, blocks breast cancer cellular metastasis and enhances cell death induced by DNA damaging chemotherapy. Breast Cancer Res. 2021 Jan 23; 23(1):11. doi: 10.1186/s13058-021-01391-1. PMID: 33485378

  5. Jiao X, Tian L, Zhang Z, Balcerek J, Kossenkov AV, Casimiro MC, Wang C, Liu Y, Ertel A, Soccio RE, Chen ER, Liu Q, Ashton AW, Tong W, Pestell RG. Pparγ1 Facilitates ErbB2-Mammary Adenocarcinoma in Mice. Cancers (Basel). 2021 Apr 30; 13(9):2171. doi: 10.3390/cancers13092171. PMID: 33946495

  6. (Equal first author) Chen K, Jiao X, Ashton A, Di Rocco A, Pestell TG, Sun Y, Zhao J, Casimiro MC, Li Z, Lisanti MP, McCue PA, Shen D, Achilefu S, Rui H, Pestell RG. The membrane-associated form of cyclin D1 enhances cellular invasion.Oncogenesis. 2020 Sep 18; 9(9):83. doi: 10.1038/s41389-020-00266-y. PMID: 32948740

  7. (Equal first author) Chen K, Jiao X, Di Rocco A, Shen D, Xu S, Ertel A, Yu Z, Di Sante G, Wang M, Li Z, Pestell TG, Casimiro MC, Skordalakes E, Achilefu S, Pestell RG. Endogenous Cyclin D1 Promotes the Rate of Onset and Magnitude of Mitogenic Signaling via Akt1 Ser473 Phosphorylation. Cell Rep. 2020 Sep 15; 32(11):108151. doi: 10.1016/j.celrep.2020.108151. PMID: 32937140

  8. (Equal first author) Li Z, Jiao X, Di Sante G, Ertel A, Casimiro MC, Wang M, Katiyar S, Ju X, Klopfenstein DV, Tozeren A, Dampier W, Chepelev I, Jeltsch A, Pestell RG. Cyclin D1 integrates G9a-mediated histone methylation. Oncogene. 2019 May; 38(22):4232-4249. doi: 10.1038/s41388-019-0723-8. Epub 2019 Feb 4. PMID: 30718920

  9. Jiao X, Li Z, Wang M, Katiyar S, Di Sante G, Farshchian M, South AP, Cocola C, Colombo D, Reinbold R, Zucchi I, Wu K, Tabas I, Spike BT, Pestell RG. Dachshund Depletion Disrupts Mammary Gland Development and Diverts the Composition of the Mammary Gland Progenitor Pool. Stem Cell Reports. 2019 Jan 8; 12(1):135-151. doi: 10.1016/j.stemcr.2018.11.010. Epub 2018 Dec 13. PMID: 30554919

  10. Jiao X, Velasco-Velázquez MA, Li Z, Rui H, Korkola JE, Chen X, Xu S, Guerrero-Rodriguez S, Addya S, Sicoli D, Mu Z, Zhang G, Stucky A, Zhang X, Cristofanilli M, Fatatis A, Gray JW, Zhong JF, Pestell RG. CCR5 governs DNA damage repair and breast cancer stem cell expansion. Cancer Res. 2018 Apr 1; 78(7):1657-1671. doi: 10.1158/0008-5472.CAN-17-0915. Epub 2018 Jan 22. PMID: 29358169

  11. (Equal first author) Pestell TG, Jiao X, Kumar M, Peck AR, Prisco M, Deng S, Ertel A, Casimiro MC, Ju X, Di Rocco1 A, Di Sante G, Katiyar S, Shupp A, Lisanti MP, Jain P, Wu K, Rui H, Hooper DC, Yu Z, Goldman AR, Speicher DW, Laury-Kleintop L, Pestell RG, Stromal cyclin D1 promotes heterotypic immune signaling and cancer growth. Oncotarget, 2016 Nov 15; 76(22):6723-6734. doi: 10.1158/0008-5472.CAN-15-3327. Epub 2016 Sep 15. PMID: 27634768

  12. Casimiro MC, Di Sante G, Di Rocco A, Loro E, Pupo C, Pestell TG, Bisetto S, Velasco-Velázquez MA, Jiao X, Li Z, Kusminski CM, Seifert EL, Wang C, Ly D, Zheng B, Shen CH, Scherer PE, Pestell RG. Cyclin D1 Restrains Oncogene-Induced Autophagy by Regulating the AMPK-LKB1 Signaling Axis. Cancer Res. 2017 Jul 1;77(13):3391-3405. doi: 10.1158/0008-5472.CAN-16-0425. Epub 2017 May 18. PMID: 28522753

  13. (Equal first author) Ju X, Jiao X, Ertel A, Casimiro MC, Di Sante G, Deng S, Li Z, Di Rocco A, Zhan T, Hawkins A, Stoyanova T, Andò S, Fatatis A, Lisanti MP, Gomella LG, Languino LR, Pestell RG. v-Src Oncogene Induces Trop2 Proteolytic Activation via Cyclin D1. Cancer Res. Cancer Res. 2016 Nov 15; 76(22):6723-6734. doi: 10.1158/0008-5472.CAN-15-3327. Epub 2016 Sep 15. PMID: 27634768

  14. Chen K, Wu K, Jiao X, Wang L, Ju X, Wang M, Di Sante G, Xu S, Wang Q, Li K, Sun X, Xu C, Li Z, Casimiro MC, Ertel A, Addya S, McCue PA, Lisanti MP, Wang C, Davis RJ, Mardon G, Pestell RG. The endogenous cell-fate factor dachshund restrains prostate epithelial cell migration via repression of cytokine secretion via a cxcl signaling module. Cancer Res. 2015 May 15;75(10):1992-2004. doi: 10.1158/0008-5472.CAN-14-0611. Epub 2015 Mar 13. PMID: 25769723

  15. Di Sante G, Wang L, Wang C, Jiao X, Casimiro MC, Chen K, Pestell TG, Yaman I, Di Rocco A, Sun X, Horio Y, Powell MJ, He X, McBurney MW, Pestell RG. Sirt1-Deficient Mice Have Hypogonadotropic Hypogonadism due to Defective GnRH Neuronal Migration. Mol Endocrinol. 2015 Feb; 29(2):200-12. doi: 10.1210/me.2014-1228. Epub 2014 Dec 29. PMID: 25545407

  16. (Equal first author) Sicoli D, Jiao X, Ju X, Velasco-Velazquez M, Ertel A, Addya S, Li Z, Andò S, Fatatis A, Paudyal B, Cristofanilli M, Thakur ML, Lisanti MP, Pestell RG. CCR5 receptor antagonists block metastasis to bone of v-Src oncogene-transformed metastatic prostate cancer cell lines. Cancer Res. 2014 Dec 1; 74(23):7103-14. doi: 10.1158/0008-5472.CAN-14-0612. PMID: 25452256

  17. Li Z, Chen K, Jiao X, Wang C, Willmarth NE, Casimiro MC, Li W, Ju X, Kim SH, Lisanti MP, Katzenellenbogen JA, Pestell RG. Cyclin D1 integrates estrogen-mediated DNA damage repair signaling. Cancer Res. 2014 Jul 15; 74(14):3959-70. doi: 10.1158/0008-5472.CAN-13-3137. Epub 2014 May 15. PMID: 24830723

  18. Ju X, Casimiro MC, Gormley M, Meng H, Jiao X, Katiyar S, Crosariol M, Chen K, Wang M, Quong AA, Lisanti MP, Ertel A, Pestell RG. Identification of a cyclin D1 network in prostate cancer that antagonizes epithelial-mesenchymal restraint. Cancer Res. 2014 Jan 15; 74(2):508-19. doi: 10.1158/0008-5472.CAN-13-1313. Epub 2013 Nov 26. PMID: 24282282

  19. Wu K, Chen K, Wang C, Jiao X, Wang L, Zhou J, Wang J, Li Z, Addya S, Sorensen PH, Lisanti MP, Quong A, Ertel A, Pestell RG. Cell fate factor DACH1 represses YB-1-mediated oncogenic transcription and translation. Cancer Res. 2014 Feb 1; 74(3):829-39. doi: 10.1158/0008-5472.CAN-13-2466. Epub 2013 Dec 12. PMID: 24335958

  20. (Equal first author) Velasco-Velazquez M, Jiao X, De La Fuente M, Pestell TG, Ertel A, Lisanti MP, Pestell RG. CCR5 antagonist blocks metastasis of basal breast cancer cells. Cancer Res. 2012 Aug 1;72(15):3839-50. doi: 10.1158/0008-5472.CAN-11-3917. Epub 2012 May 25. PMID: 22637726

  21. Bonuccelli G, Castello-Cros R, Capozza F, Martinez-Outschoorn UE, Lin Z, Tsirigos A, Jiao X, Whitaker-Menezes D, Howell A, Lisanti MP, Sotgia F. The milk protein α-casein functions as a tumor suppressor via activation of STAT1 signaling, effectively preventing breast cancer tumor growth and metastasis. Cell Cycle. 2012 Nov 1;11(21):3972-82. doi: 10.4161/cc.22227. Epub 2012 Oct 9. PMID: 23047602

  22. (Equal first author) Katiyar S, Jiao X, Addya S, Ertel A, Rose V, Casimiro MC, Zhou J, Lisanti MP, Nasim T, Fortina P, Pestell RG. Mammary gland selective excision of c-jun identifies its role in mRNA splicing. Cancer Res. 2012 Feb 15; 72(4):1023-34. doi: 10.1158/0008-5472.CAN-11-3647. Epub 2011 Dec 15. PMID: 22174367

  23. (Equal first author) Janowski E, Jiao X, Katiyar S, Lisanti MP, Liu M, Pestell RG, Morad M. c-Jun is required for TGF-β-mediated cellular migration via nuclear Ca2+ signaling. Int J Biochem Cell Biol. 2011 Aug;43(8):1104-13. doi: 10.1016/j.biocel.2011.03.011. Epub 2011 Apr 5. PMID: 21447400

  24. Meng H, Tian L, Zhou J, Li Z, Jiao X, Li WW, Plomann M, Xu Z, Lisanti MP, Wang C, Pestell RG. PACSIN 2 represses cellular migration through direct association with cyclin D1 but not its alternate splice form cyclin D1b. Cell Cycle. 2011 Jan 1; 10(1):73-81. doi: 10.4161/cc.10.1.14243. Epub 2011 Jan 1. PMID: 21200149

  25. Liu M, Sakamaki T, Casimiro MC, Willmarth NE, Quong AA, Ju X, Ojeifo J, Jiao X, Yeow WS, Katiyar S, Shirley LA, Joyce D, Lisanti MP, Albanese C, Pestell RG. The canonical NF-kappaB pathway governs mammary tumorigenesis in transgenic mice and tumor stem cell expansion. Cancer Res. 2010 Dec 15; 70(24):10464-73. doi: 10.1158/0008-5472.CAN-10-0732. PMID: 21159656

  26. Li Z, Jiao X, Wang C, Shirley LA, Elsaleh H, Dahl O, Wang M, Soutoglou E, Knudsen ES, Pestell RG. Alternative cyclin D1 splice forms differentially regulate the DNA damage response. Cancer Res. 2010 Nov 1; 70(21):8802-11. doi: 10.1158/0008-5472.CAN-10-0312. Epub 2010 Oct 12. PMID: 20940395

  27. Wu K, Jiao X, Li Z, Katiyar S, Casimiro MC, Yang W, Zhang Q, Willmarth NE, Chepelev I, Crosariol M, Wei Z, Hu J, Zhao K, Pestell RG. Cell fate determination factor Dachshund reprograms breast cancer stem cell function. J Biol Chem. 2011 Jan 21; 286(3):2132-42. doi: 10.1074/jbc.M110.148395. Epub 2010 Oct 11. PMID: 20937839

  28. Xiong JW, Zhu L, Jiao X, Liu SS. Evidence for DeltapH surface component (DeltapH(S)) of proton motive force in ATP synthesis of mitochondria. Biochim Biophys Acta. 2010 Mar; 1800(3):213-22. doi: 10.1016/j.bbagen.2009.07.032. Epub 2009 Aug 17. PMID: 19695309

  29. Jiao X, Katiyar S, Willmarth NE, Liu M, Ma X, Flomenberg N, Lisanti MP, Pestell RG. C-Jun induces mammary epithelial cellular invasion and breast cancer stem cell expansion. J Biol Chem. 2010 Mar 12; 285(11):8218-26. doi: 10.1074/jbc.M110.100792. Epub 2010 Jan 6. PMID: 20053993

  30. Liu M, Casimiro MC, Wang C, Shirley LA, Jiao X, Katiyar S, Ju X, Li Z, Yu Z, Zhou J, Johnson M, Fortina P, Hyslop T, Windle JJ, Pestell RG. p21CIP1 attenuates Ras- and c-Myc-dependent breast tumor epithelial mesenchymal transition and cancer stem cell-like gene expression in vivo. Proc Natl Acad Sci USA. 2009 Nov 10; 106(45):19035-9. doi: 10.1073/pnas.0910009106. Epub 2009 Oct 26. PMID: 19858489

  31. Liu M, Ju X, Willmarth NE, Casimiro MC, Ojeifo J, Sakamaki T, Katiyar S, Jiao X, Popov VM, Yu Z, Wu K, Joyce D, Wang C, Pestell RG. Nuclear factor-kappaB enhances ErbB2-induced mammary tumorigenesis and neoangiogenesis in vivo. Am J Pathol. 2009 May;174(5):1910-20. doi: 10.2353/ajpath.2009.080706. Epub 2009 Apr 6. PMID: 19349372

  32. Wu K, Katiya S, Li A, Liu M, Ju X, Popov V, Jiao X, Lisanti MP, Antonella, C, Pestell RG. Dachshund inhibits oncogene-induced breast cancer cellular migration and invasion through suppression of interleukin-8. Proc Nat Acad Sci. USA. 2008 May 13;105(19):6924-9. doi: 10.1073/pnas.0802085105. Epub 2008 May 8. PMID: 18467491

  33. Qiu Q, Wang RY, Jiao X, Jin B, Sugauchi F, Grandinetti T, Alter HJ, Shih JW. Induction of multispecific Th-1 type immune response against HCV in mice by protein immunization using CpG and Montanide ISA 720 as adjuvants. Vaccine. 2008 Oct 9 ;26(43):5527-5534. doi: 10.1016/j.vaccine. 2008.07.034. Epub 2008 Sep 2. PMID: 18675871

  34. Lindsay J, Jiao X, Sakamaki T, Casimiro MC, Shirley LA, Tran TH, Ju X, Liu M, Li Z, Wang C, Katiya S, Rao M, Allen KG, Glazer RI, Ge C, Stanley P, Lisanti MP, Rui H, Richard RG. ErbB2 induces Notch1 activity and function in breast cancer cells. Clin Transl Sci. 2008 Sep;1(2):107-15. doi: 10.1111/j.1752-8062.2008.00041.x. PMID: 20443831

  35. Jiao X, Katiyar S, Liu M, Mueller SC, Lisanti MP, Li A, Pestell TG, Wu K, Ju X, Li Z, Wagner EF, Takeya T, Wang C, Pestell RG. Disruption of c-Jun Reduces Cellular Migration and Invasion through Inhibition of c-Src and Hyperactivation of ROCK II Kinase. Mol Biol Cell. 2008 Apr; 19(4):1378-90. doi: 10.1091/mbc.e07-08-0753. Epub 2008 Jan 23. PMID: 18216279

  36. Li Z, Wang C, Jiao X, Katiyar S, Casimiro MC, Prendergast GC, Powell MJ, Pestell RG. Alternate cyclin D1 mRNA splicing modulates p27KIP1 binding and cell migration. J Biol Chem. 2008 Mar 14; 283(11):7007-15. doi: 10.1074/jbc.M706992200. Epub 2008 Jan 7. PMID: 18180298

  37. Ju X, Katiyar S, Wang C, Liu M, Jiao X, Li S, Zhou J, Turner J, Lisanti MP, Russell RG, Mueller SC, Ojeifo J, Chen WS, Hay N, Pestell RG. Akt1 governs breast cancer progression in vivo. Proc Nat Acad Sci USA. 2007 May 1; 104(18):7438-43. doi: 10.1073/pnas.0605874104. Epub 2007 Apr 25. PMID: 17460049

  38. Wu K, Liu M, Li A, Donninger H, Rao M, Jiao X, Lisanti MP, Cvekl A, Birrer M, Pestell RG. The cell fate determination factor DACH1 inhibits c-Jun induced contact-independence growth. Mol Biol Cell. 2007 Mar;18(3):755-67. doi: 10.1091/mbc.e06-09-0793. Epub 2006 Dec 20. PMID: 17182846

  39. Katiyar S, Jiao X, Wagner E, Lisanti MP, Pestell RG. Somatic Excision demonstrates c-jun regulates cellular adhesion and migration through induction of stem cell factor. Mol Cell Biol. 2007 Feb; 27(4):1356-69. doi: 10.1128/MCB.01061-06. Epub 2006 Dec 4. PMID: 17145782

  40. Fu M, Liu M, Sauve AA, Jiao X, Zhang X, Powell M, Yang T, Gu W, Avantaggiati N, Pestell TG, Wang F, Quong A, Wang C, Pestell RG. Hormonal control of androgen receptor function through SIRT1. Mol Cell Biol. 2006 Nov; 26(21):8122-35. doi: 10.1128/MCB.00289-06. Epub 2006 Aug 21. PMID: 16923962

  41. Li Z, Jiao X, Wang C, Ju X, Lu Y, Yuan L, Lisanti MP, Katiyar S, Pestell RG. Cyclin D1 induction of cellular migration requires p27kip1. Cancer Res. 2006 Oct 15; 66(20):9986-94. doi: 10.1158/0008-5472.CAN-06-1596. PMID: 17047061

  42. Sakamaki T, Casimiro MC, Ju X, Quong AA, Katiyar S, Liu M, Jiao X, Li A, Zhang X, Lu Y, Wang C, Byers S, Nicholson R, Link T, Shemluck M, Yang J, Fricke ST, Novikoff PM, Papanikolaou A, Arnold A, Albanese C, Pestell RG. Cyclin D1 determines mitochondrial function in vivo. Mol Cell Biol. 2006 Jul; 26(14):5449-69. doi: 10.1128/MCB.02074-05. PMID: 16809779

  43. Li Z, Wang C, Jiao X, Lu Y, Fu M, Quong AA, Dye C, Yang J, Dai M, Ju X, Zhang X, Li A, Burbelo P, Stanley EP, Pestell RG. Cyclin D1 regulatescellular migration through the inhibition of thrombospondin-1 and ROCK signaling. Mol Cell Biol 2006 Jun; 26(11):4240-56. doi: 10.1128/MCB.02124-05. PMID: 16705174

  44. Kramer JM, Yi L, Shen F, Maitra M, Jiao X, Jin T, Gaffen SL. Cutting Edge: Evidence for Ligand-Independent Multimerization of the IL-17 Receptor. J Immunol. 2006 Jan 15; 176(2):711-5. doi: 10.4049/jimmunol.176.2.711. PMID: 16393951

  45. Fu M, Wang C, Rao M, Wu X, Bouras T, Zhang X, Li Z, Jiao X, Yang J, Li A, Perkins ND, Thimmapaya B, Kung AL, Munoz A, Giordano A, Lisanti MP, Pestell RG. Cyclin D1 represses p300 transactivation through a cyclin-dependent kinase-independent mechanism. J Biol Chem. 2005 Aug 19;280(33):29728-42. doi: 10.1074/jbc.M503188200. Epub 2005 Jun 10. PMID: 15951563

  46. Jiao X, Zhang N, Xu X, Oppenheim JJ, Jin T. Ligand-induced partitioning of human CXCR1 chemokine receptors with lipid raft microenvironments facilitates G-protein-dependent signaling. Mol Cell Biol. 2005 Jul;25(13):5752-62. doi: 10.1128/MCB.25.13.5752-5762.2005. PMID: 15964828

  47. Xu X, Meier-Schellersheim M, Jiao X, Nelson L, Jin T. Quantitative imaging of single live cells reveals spatiotemporal dynamics of multi-step signaling events of chemoattractant gradient sensing in Dictyostelium. Mol Biol Cell. 2005 Feb;16(2):676-88. doi: 10.1091/mbc.e04-07-0544. Epub 2004 Nov 24. PMID: 15563608

  48. Jiao X, Wang RY-H, Qiu Q, Alter HJ, Shih JW-K. Enhanced HCV NS3 specific Th1 immune responses induced by co-delivery of protein antigen and CpG with cationic liposomes. J Gen Virol. 2004 Jun;85(Pt 6):1545-1553. doi: 10.1099/vir.0.79896-0. PMID: 15166438

  49. Jiao X, Wang RY-H, Feng Z-M, Hu G-J, Alter HJ, Shih JW-K. DNA immunization encoding the secreted nonstructural protein 3 (NS3) of hepatitis C virus and enhancing the Th1 type immune response. J Viral Hepatitis. 2004 Jan; 11(1):18-26. doi: 10.1046/j.1352-0504.2003.00464.x. PMID: 14738554

  50. Jiao X, Wang RY-H, Feng Z, Alter HJ, Shih JW-K. Modulation and enhancement of cellular immune response against non-structural protein 3 of hepatitis C virus by DNA immunization with cationic liposomes. Hepatology. 2003 Feb; 37(2):452-60. doi: 10.1053/jhep.2003.50051. PMID: 12540796

  51. Jiao XM, Li QH, Li LJ, Xu M, Xiong JW, Liu SS, Shen ZW. Effects of calcium and ratio of phosphotidylethanolamine to phosphotidylcholine on the fusion of Ehrlich ascites cell plasma membrane with liposomes driven by transmembrane pronton translocation. Acta Zoologica Sinica. 2002, 48(5), 660-666 (in Chinese)

  52. Jiao XM, Zhu LP, Yu J, Shen ZW. The Proton in membrane Surface may be the major driven force of ATP sythesis, Acta Biophysica Sinca. 1998, 14(4): 623-628 (in Chinese)

  53. Jiao XM, Xiong JW, Liu SS. Using a fluorescein derivative of phosphhatidyl-ethanolamine for direct measurement of interfacial pH of mitoplast membranes. Acta Zoologica Sinica. 1997, 43(1): 96-102.

  54. Jiao XM, Xu M, Wei YY, Li LJ, Liu SS. High energy protons on mitoplast membrane interface upon succinate oxidation and its significance in energy coupling function. Acta Zoologica Sinica. 1996, 42(1): 96-104 (in Chinese)

  55. Liu SS, Jiao XM; Wang XM, Zhang L. Interaction of electron leak and proton leak in respiratory chain of mitochondria, proton leak induced by superoxide from an electron leak pathway of univalent reduction of oxygen. Science in China(C). 1996 Apr; 39(2):168-78. PMID: 8760464

    Chinese Version: Liu SS, Jiao XM; Wang XM, Zhang L. Interaction of electron leak and proton leak in respiratory chain of mitochondria, proton leak induced by superoxide from an electron leak pathway of univalent reduction of oxygen. Science in China (B). 1995, 25(6): 596-603

  56. Hu G-J, Jiao XM, Gao SR, Duan CW, Li MW and Chen DY. Anti-sperm antibody inhibits spermatozoa acrosome reaction (AR) induced by progesterone and affects the free Ca2+ changes in spermatozoa. Chinese Science Bulletin. 1996, 41(17): 1466-1471

  57. Su XH, Jiang XS, Wang XM; Jiao XM, Liu SS. The effect of captopril on proton-electron coupling and oxidative phosphorylation of cardiac mitochondria during ischemia reperfusion. Chinese Journal of Pathophysiology. 1996, 12(3): 316-319 (in Chinese)

  58. Su XH, Wang XM, Zhu SJ; Jiao XM, Zhu LP, Liu SS. The effect of angiotension II (AGT II) on the respiratory function and transmembrane potential of isolated cardiac mitochondria. Chinese Journal of Pathophysiology. 1996, 12: 313-315 (in Chinese)

  59. Su XH, Wang XM, Zhu SJ; Jiao XM, Liu SS. Changes of transmembrane potential and the ATPase synthetic activity in mitochondria and mitoplast of rat myocardium during ischemia\reperfusion. Chinese Journal of Pathophysiology. 1996, 12(2): 190-193 (in Chinese)

  60. Su XH, Wang XM; Jiao XM, Liu SS. The changes of proton-electron coupling and oxidative phosphorylation in mitoplast during early stage of myocardial ischemia reperfusion and the protective effect of DS-182. Chinese Journal of Pathophysiology. 1996, 12(2): 186-189 (in Chinese)

  61. Zhang L, Wang XM, Zhu SJ; Jiao XM, Liu SS. The effect of superoxide anion on transmembrane potential and proton transfer of myocardial mitochondria. Chinese Journal of Pathophysiology. 1996, 12(2): 181-185 (in Chinese)

  62. Jiao XM, Liu SS. Proton translocation can induce plasma-membrane protonation of Ehrlich ascites cells. Acta Biophysica Sinca. 1995, 11(2): 185-190 (in Chinese)

  63. Jiao XM, Xu HL, Liu SS. Transmembrane proton translocation decreases hydrophilicity of plasma membrane surface in Ehrlich ascites cells. Chinese Science Bulletin. 1995, 40(18): 1562-1567

    Chinese version: Jiao XM, Xu HL, Liu SS. Transmembrane proton translocation decreases hydrophilicity of plasma membrane surface in Ehrlich ascites cells. Chinese Science Bulletin. 1995, 40(4): 354-357

  64. Jiao XM, Zhou TQ, Liu SS; Miao MY, Feng WH, Chen KM. The effects of Tenshone II A-sulfonate on the function of rat liver mitoplast. Chinese Biochemical Journal. 1995, 11(3): 292-296 (in Chinese)

  65. Zhou TQ, Jiao XM, Wei YY, Liu SS, Feng WH., Miao MY. Proton leakage is the mechanism for hematoporphyrin photosensitization-promoted inactivation of rat liver mitochondria. Progress in Natural Science. 1995, 5(4): 410-418

    Chinese version: Zhou TQ, Jiao XM, Wei YY, Liu SS, Feng WH, Miao MY. Proton leakage is the mechanism for hematoporphyrin photosensitization-promoted inactivation of rat liver mitochondria. Progress in Natural Science. 1994, 4(3): 313-318

  66. Zhu LP, Jiao XM, Li CY, Liu SS. Mebrane fluidity and respiratory chain coupling of energized mitoplast. Acta Biochimica et Biophysica Sinica. 1995, 27(6): 643-650 (in Chinese)

  67. Wei YY, Jiao XM, Liu SS. Coupling between electron transfer and proton pumping in respiratory chain complex II+III of rat liver mitoplast. Chinese Biochemical Journal. 1995, 11(5): 593-599 (in Chinese)

  68. Zhu SJ, Wang XM; Jiao XM, Liu SS. The influence of oxygen free radicals on synthetic and hydrolytic activities of H+-ATPase in mitochondria of rat myocardium and the protective effect of DS-182. Chinese Journal of Pathophysiology. 1995, 11(1): 42-45 (in Chinese)

  69. Liu YX, Wang JB; Jiao XM, Ding YZ, Liu SS. The reduction in blood glucose level by gastrointestinal administration of liposome encapsulated insulin. In Progress in Research of Life Science, ed. by Executive Committee of Second Youth Academic Annual Metting of China Association for Science and Technology. Chinese Science and Technology Press, Beijing. 1995, p669-673 (in Chinese)

  70. Jiao XM, Gao FH, Liu SS, Membrane fusion of Ehrlich's ascites cells with liposomes driven by proton translocation across plasma membranes, Progress in Natural Sciences, 1994, 4(2): 209-216 (in Chinese)

  71. Jiao XM, Xu HL, Liu SS. Membrane fusion-induced factors cause a decrease in membrane surface dielectric constant. Acta Biophysica Sinica. 1994, 10(3): 417-420 (in Chinese)

  72. Jiao XM, Xu HL, Liu SS. Molecular mechanism of membrane fusion: proton pumping activity and dehydration of membrane surface. In Sixtieth Anniversary of the founding of China Zoological Society: Memorial Volume Dedicated to the Hundredth Anniversary of the Birthday of the Late Prof. Sisan Chen. Ed. by China Zoological Society et al. Chinese Science and Technology Press, Beijing. 1994, p263-272 (in Chinese)

  73. Liu SS, Xu HL, Jiao XM. Energization and local dehydration of mitochondria and mitoplast membrane surface. Acta Biophysica Sinica. 1994, 10(1): 57-62 (in Chinese)

  74. Zhou JQ, Cao XH, Cen XN; Jiao XM, Liu SS. The activity of trans-plasma redox system in erythrocytes of patients with iron deficiency anemia (IDA) and leukemia. Chinese Journal of Experimental Hematology. 1994, 2(1):79-83 (in Chinese)

  75. Zhu SJ, Wang XM; Jiao XM, Liu SS. Investigation of synthetic and hydrolytic activities of H+-ATPase in myocardial mitochondria with ischemia/reperfusion injury and protective effect of DS182. Chinese Journal of Pathophysiology. 1994, 10(7): 674-677 (in Chinese)

  76. Zhu SJ, Wang XM, Ma XC; Jiao XM, Liu SS. Primary research of ATP synthesis by adenylate kinase in myocardial mitochondria of rat. Chinese Journal of Pathophysiology. 1994, 10(7): 704-695 (in Chinese)

  77. Xu HL, Jiao XM, Liu SS. Fluorescence measurement of surface dielectric constant of cell membrane. Acta Biophysica Sinica. 1993, 9(2): 234-239 (in Chinese)

  78. Zhang H, Jiao XM, Liu SS; Wang XM. The effect of ischemia and reperfusion on energy transductional function of rat heart mitochondrial. Chinese Journal of Pathophysiology. 1993, 9(5): 561-564 (in Chinese)

  79. Liu SS, Xiong JW, Jiao XM. Energy Coupling Function and Proton Current Pathways of Redox Pumps in Mitochondria. Proceedings of International Symposium of Modern Trends in Protein and Enzyme Research. Organized by Institute of Biophysics. Academia Sinica, Beijing. 1993, p270-281

  80. Wang XM, Miao MY, Chen KM; Jiao XM, Zhu LP, Liu SS. Regulation of H+ transmembrane Transport activity in rat liver mitochondria during acute stress. Chinese Biochemical Journal. 1993, 9(6): 725-729 (in Chinese)

  81. Chang YZ, Liang DQ, Wang XM; Liu SS, Jiao XM. Protective effect of DS-182 on the H+-ATPase activity of rat myocardial mitochondria against free radical damage. Chinese Journal of Pathophysiology. 1991, 7(5): 449-452 (in Chinese)

 

PATENTS

  • Pestell RG, Cristofanilli M, Jiao X. Cancers expressing CCR5 and methods of treatment of same. Pub. Date: Oct. 25, 2018. Pub. No.: US 2018/0303830.A1

  • Pestell RG, Wu K, Jiao X, Katiya S, Popov VM, Casmiro M. Methods and compositions for the diagnosis, prognosis and treatment of Cancer. Pub. Date: Jan. 10, 2013. Pub. No.: US 2013/0011411.A1

     

REVIEW AND BOOK CHAPTERS:

  1. (Co-corresponding author) Ashton AW, Dhanjal HK, Rossner B, Mahmood H, Patel VI, Nadim M, Lota M, Shahid F, Li Z, Joyce D, Pajkos M, Dosztányi Z, Jiao X, Pestell RG. Acetylation of nuclear receptors in health and disease: an update. FEBS J. 2024 Jan;291(2):217-236. doi: 10.1111/febs.16695. Epub 2022 Dec 19. PMID: 36471658

  2. (Co-corresponding author) Hamid R, Alaziz M, Mahal AS, Ashton AW, Halama N, Jaeger D, Jiao X, Pestell RG. The Role and Therapeutic Targeting of CCR5 in Breast Cancer. Cells. 2023 Sep 8;12(18):2237. doi: 10.3390/cells12182237. PMID: 37759462; PMCID: PMC10526962

  3. (Co-corresponding author) Abdelmalak M, Singh R, Anwer M, Ivanchenko P, Randhawa A,  Ahmed A, Ashton AW, Du Y, Jiao X, Pestell RG. The Renaissance of CDK Inhibitors in Breast Cancer Therapy: An Update on Clinical Trials and Therapy Resistance. Cancers. 2022 Nov 1; 14(21):5388. doi: 10.3390/cancers14215388. PMID: 36358806

  4. (Corresponding author) Jiao X, Upadhyaya C, Zhang Z, Zhao J, Li Z, Patel VI, Pestell RG. Assays for the Spectrum of Circulating Tumor Cells. Methods Mol Biol. 2022;2429:533-545. doi: 10.1007/978-1-0716-1979-7_37. PMID: 35507187

  5. Lah Turnšek T, Jiao X, Novak M, Jammula S, Cicero G, Ashton AW, Joyce D, Pestell RG. An Update on Glioblastoma Biology, Genetics, and Current Therapies: Novel Inhibitors of the G Protein-Coupled Receptor CCR5. Int J Mol Sci. 2021 Apr 24;22(9):4464. doi: 10.3390/ijms22094464. PMID: 33923334

  6. (Co-corresponding author) Patra S, Elahi N, Armorer A, Arunachalam S, Omala J, Hamid I, Ashton AW, Joyce D, Jiao X, Pestell RG. Mechanisms Governing Metabolic Heterogeneity in Breast Cancer and Other Tumors. Front Oncol. 2021 Sep 23;11:700629. doi: 10.3389/fonc.2021.700629. eCollection 2021. PMID: 34631530

  7. Upadhyaya C, Jiao X, Ashton A, Patel K, Kossenkov AV, Pestell RG. The G protein coupled receptor CCR5 in cancer. Adv Cancer Res. 2020;145:29-47. doi: 10.1016/bs.acr.2019.11.001. Epub 2020 Jan 10. PMID: 32089164

  8. Jiao X, Nawab O, Patel T, Kossenkov AV, Halama N, Jaeger D, Pestell RG. Recent Advances Targeting CCR5 for Cancer and Its Role in Immuno-Oncology. Cancer Res. 2019, 79(19):4801-4807. doi: 10.1158/0008-5472.CAN-19-1167. Epub 2019 Jul 10. PMID: 31292161

  9. Di Sante G, Pagé J, Jiao X, Nawab O, Cristofanilli M, Skordalakes E, Pestell RG.Recent advances with cyclin-dependent kinase inhibitors: therapeutic agents for breast cancer and their role in immuno-oncology. Expert Rev Anticancer Ther. 2019 Jul;19(7):569-587. doi: 10.1080/14737140.2019.1615889. Epub 2019 Jun 20. PMID: 31219365

  10. Jiao X, Rizvanov AA, Cristofanilli M, Miftakhova RR, Pestell RG. Breast Cancer Stem Cell Isolation. Methods Mol Biol. 2016;1406:121-35. doi: 10.1007/978-1-4939-3444-7_10. PMID: 26820950

  11. Pestell RG, Fatatis A, Jiao X. Mitochondrial mass and DNA repair in breast cancer stem cells. Oncotarget. 2015 Nov 17;6(36):38442-3. doi: 10.18632/oncotarget.6305. PMID: 26564961

  12. Sun X, Jiao X, Pestell TG, Fan C, Qin S, Mirabelli E, Ren H, Pestell RG. MicroRNAs and cancer stem cells: the sword and the shield. Oncogene. 2014 Oct 16; 33(42):4967-77. doi: 10.1038/onc.2013.492. Epub 2013 Nov 18. PMID: 24240682

  13. Velasco-Velázquez MA, Jiao X, Pestell RG. Breast cancer stem cells. in Cancer Stem Cells Theories and Practice. ed. by Shostak S. InTech - Open Access Publisher, Rijeka, Croatia. 2011, p63-78.

  14. Velasco-Velázquez MA, Yu Z, Jiao X, Pestell RG. Cancer stem cells and the cell cycle: targeting the drive behind breast cancer. Expert Rev Anticancer Ther. 2009 Mar; 9(3):275-9. doi: 10.1586/14737140. 9.3.275. PMID: 19275505

  15. Jiao X, Xu X, Shih JW-K, Chapter 49, Development of Hepatitis C Virus (HCV) vaccines. in Vaccinology. ed. by Zhang Y. Science Press, Beijing, China. 2004, p1155-1165 (in Chinese).